- The Step 1 Newsletter
- Posts
- Which of the following is most likely to be found on urinalysis?
Which of the following is most likely to be found on urinalysis?
Morning Quiz ☕
A 57-year-old man presents to the hospital with the following symptoms:
Nausea and vomiting
Severe cramping pain in the right flank
Additional History:
No fever or chills
Similar, but milder, pain occurred a few days ago and resolved spontaneously
Medical History:
Type 2 diabetes mellitus
Obesity
Hyperlipidemia
Hypertension
Gout
Vital Signs:
Temperature: 37°C (98.6°F)
Blood pressure: 160/100 mm Hg
Pulse: 98/min
Physical Examination:
Right flank tenderness
Laboratory Findings:
Blood urea nitrogen (BUN): Normal
Serum creatinine: Normal
Imaging Findings (Abdominal Ultrasound):
Right-sided hydronephrosis
Proximal ureteral dilation

Question:
Based on this presentation, which of the following is most likely to be found on urinalysis?
Options:
A. Malignant cells
B. Red blood cells
C. Red blood cell casts
D. Specific gravity of 1.002
E. White blood cell casts

Correct Answer 🎯: B. Red Blood Cells
⚙️
🧠 Obesity + Hyperlipidemia + Hypertension + Type 2 Diabetes Mellitus
⬇
↑ Risk of uric acid stone formation (gout history) and calcium oxalate stones (obesity, hyperlipidemia, diabetes)
⬇
Metabolic Dysregulation → ↑ Uric acid and calcium excretion in urine
⬇
🧠 Hyperuricemia + Hypercalciuria + Dehydration (if present)
⬇
Crystallization in the renal tubules or collecting system
⬇
Nephrolithiasis (kidney stone formation)
(think of a “clogged pipe 🚰” in the urinary system)
⬇
🧠 Stone moves from renal pelvis to ureter
⬇
Obstruction of the right ureter (proximal ureteral dilation on ultrasound)
⬇
Hydronephrosis (right-sided, as seen on ultrasound)
(“balloon inflating 🎈”)
⬇
🧠 Ureteral obstruction
⬇
↑ Intraluminal pressure in the renal pelvis and ureter
⬇
Stretching of the renal capsule and ureter
(like “stretching a rubber band 🎗️”)
⬇
Severe crampy right flank pain (renal colic)
⬇
🧠 Obstruction + Stretching
⬇
Activation of renal afferent nerves
⬇
Nausea and vomiting (visceral autonomic response)
🧠 Mechanical trauma from the stone
⬇
Damage to urothelium
⬇
Hematuria (red blood cells in urine) → Correct Answer: B. Red Blood Cells
(like “scratches on a wall 🪨”)

⚖️ Differential Table
Differential ⚖️ | Mechanism ⚙️ | Why Incorrect? 🔴 |
---|---|---|
Pyelonephritis | Bacterial infection of the kidney causing WBC casts, fever, and flank pain. | No fever, chills, or WBC casts on urinalysis. |
Glomerulonephritis | Immune-mediated glomerular injury causing RBC casts, proteinuria, and edema. | No proteinuria, hypertension, or edema; RBC casts absent. |
Urinary Tract Infection | Bacterial infection in the bladder or urethra causing dysuria and WBCs | No dysuria, fever, or WBCs in urine. |
Diabetes Insipidus | Inability to concentrate urine, leading to dilute urine (specific gravity ⬇). | Patient is likely dehydrated; specific gravity would be high, not low. |
📝 Flashcards
Stay Hungry, Stay Curious!
Success is not the key to happiness. Happiness is the key to success. If you love what you are doing, you will be successful." – Albert Schweitzer